Nat Immunol

Nat Immunol | Minxuan Sun, Shiyang Li, and Changgeng Peng found the regulatory role of NPM1 in inflammatory bowel disease and colorectal cancer

Prof. Minxuan Sun (Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences), Prof. Shiyang Li (Shandong University) and Prof. Changgeng Peng (Tongji University) jointly published a paper in Nature Immunology, titled Nucleophosmin 1 promotes mucosal immunity by supporting mitochondrial oxidative phosphorylation and ILC3 activity. The study found that nucleophosmin 1 (NPM1), a very important driver molecule in myelodysplastic syndrome and acute myeloid leukemia, plays a key role in the progression of inflammatory bowel disease.

NPM1 is involved in the molecular mechanism of intestinal homeostasis regulation by binding p65 to promote TFAM transcription, and affecting ILC3 mitochondrial function and IL22 expression. This study provides a new theoretical basis for the pathogenesis of inflammatory bowel disease and related colorectal cancer, and also the relationship between inflammatory bowel disease and myelodysplastic syndrome or acute myeloid leukemia.

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